Project Status
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We are currently integrating publicly available whole-genome sequences with our private wild mouse genome sequences.
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We have secured project funding from The Jackson Laboratory to support additional sequencing of wild mouse genomes and comprehensive analysis.
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We are actively inventorying available wild mouse tissue samples and prioritizing samples for both long- and short-read whole genome sequencing.
Analysis Areas
Data Processing and Management
Guided by FAIR principles for data management and governance, this working group is performing all aspects of data quality control, read mapping, and variant calling. This group will also spearhead the construction of wild mouse pan genome resources.
Population Genomics
This analysis subgroup is using Wild Mouse Genomes data to address fundamental questions about house mouse evolution and population genomics. Priority areas include refining current models of house mouse demographic history, identifying signals of natural selection, and characterizing relative levels of genetic variation on the autosomes and sex chromosomes.
Structural Variation
This sub-group is focused on the discovery and analysis of large-scale structural mutations in wild house mice, including the mechanisms that promote structural variants, their population genetic properties, and functional consequences. We have a particular interest in understanding why Robertsonian fusions arise frequently in wild M. m. domesticus, but not other M. musculus subspecies.
Comparisons with Lab Mice
This analysis sub-group will combine data from wild mouse genomes and diverse inbred laboratory strains to inform the origins of inbred mice, functionalize variants segregating in lab populations, and understand how wild mouse diversity can be harnessed to improve mouse models of human disease.